Human macrophage C-type lectin forms a heteromeric receptor complex with Mincle but not Dectin-2.

Despite this optimization, MCL could not be demonstrated to significantly induce expression of either Mincle (Figure 3F ) or Dectin‐2 (Figure 3G ), although a clear trend was apparent for Mincle. 3.3 Mincle can be co‐immunoprecipitated with MCL To confirm the association of human Mincle with MCL, we co‐transfected 293T cells with MCL and FcεRIγ, together with FLAG tagged Mincle, Dectin‐2 or DCIR.

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11 Although human Mincle could be expressed at reasonable levels on the cell surface in the absence of MCL, MCL did appear to enhance Mincle expression, although this effect did not reach statistical significance.

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