Correlations Between Change in Postprandial Plasma LEAP2 and AG Concentrations The postprandial increase in plasma LEAP2 iAUC 0-150 minutes in fact showed a trend to negatively correlate with the postprandial decrease in plasma AG iAUC 0-150 minutes (r s = −0.37, P = .086) (Supplementary Fig.
When comparing the absolute postprandial increase in plasma LEAP2 across this study [ 56 ], and the four analyses from three previously published studies [ 27 , 28 , 31 ] (overall two without obesity, three with obesity), there was a suggestion that the postprandial increase in plasma LEAP2 was greater with increasing energy intake at the meal, although with the small sample size this did not reach statistical significance (r s = + 0.70, P = .23) (Supplementary Fig.