The power of TOPMed imputation for the discovery of Latino-enriched rare variants associated with type 2 diabetes.

Diabetologia · 2023 · PMC10244266 · PMID 37148359

Europe PMC DOI

hedged sentences

0.0250

closest p · 0.5× alpha

0.0760

boldest claim

The sentences

nominally significantp =0.025actually significant

The meta-analysis of the replication cohorts, where the variant was present, was nominally significant and showed a consistent direction of effect with the discovery sample (OR 1.18 [95% CI 1.02, 1.36], p =0.025) (Fig. 3 c, ESM Table 5 ).

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did not reach statistical significancep =0.076so close (0.05 < p ≤ 0.1)

rs2891691 showed a larger effect and was more associated with type 2 diabetes in women (Neff 10,228; OR 2.4 [95% CI 1.73, 3.22], p =6.6 × 10 −8 ) compared with men (Neff 7206; OR 1.5 [95% CI 1.08, 2.19], p =0.018), yet the between-sex heterogeneity did not reach statistical significance ( p =0.076) (ESM Table 4 ).

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