Interestingly, we also observed a trend towards a positive correlation between portal CD79a + B cell density and serum IgG levels in VILI and AIH cases; however, it did not reach statistical significance (r s =0.639, p=0.052) ( Supplementary Fig. 3E ).
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Morphologic and molecular analysis of liver injury after SARS-CoV-2 vaccination reveals distinct characteristics.
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CD3 + CD8 + T effector cells showed a trend for a higher density in VILI than in AIH in the portal (1264 vs. 734 cells/mm 2 ) and centrilobular region (1288 vs. 739 cells/mm 2 ), which did not reach significance ( Figure 2 D).