Although the differences in inflammatory cell and TNF-α–positive cell infiltration did not reach statistical significance due to the small sample size (n = 2), there was a trend indicating that RCI001 treated groups had fewer inflammatory cells and TNF-α–positive cells infiltrating the cornea ( Fig. 3A–3E , 4A–4D ).
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Comparison of Corneal Epithelial Wound Healing between Topical RCI001, Solcoseryl, and Polydeoxyribonucleotide in the Murine Ocular Alkali Burn Model.
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In another experiment, rat cornea treated with Solcoseryl after alkali burn showed a trend of improved epithelial healing, but its difference from the control did not reach statistical significance, which agrees with the results of our study [ 34 ].