Admixture mapping implicates 13q33.3 as ancestry-of-origin locus for Alzheimer disease in Hispanic and Latino populations.

HGG Adv · 2023 · PMC10276158 · PMID 37333771

Europe PMC DOI

hedged sentences

0.1320

closest p · 2.6× alpha

0.1320

boldest claim

The sentences

failed to reach statistical significancep = 0.132not close (p > 0.1)

The smallest p value within the ADSP significant loci was observed in a variant that is also part of the most significant AD locus but failed to reach statistical significance (rs16972815; chr13:109,282,805:G:T; p = 0.132).

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nominally significantno p-value reported

While only 34 SNPs from the 13q33.3 association were nominally significant in the AGA-ALZAR samples, the occurrence of a unique AD-protective NAM variant in this region was suggested by haplotype analysis using the ADSP whole-genome sequencing data.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.