β3-adrenergic receptor on tumor-infiltrating lymphocytes sustains IFN-γ-dependent PD-L1 expression and impairs anti-tumor immunity in neuroblastoma.

Cancer Gene Ther · 2023 · PMC10281870 · PMID 36854895

Europe PMC DOI

hedged sentences

—

closest p

—

boldest claim

The sentences

an increasing trendno p-value reported

failed to reach statistical significanceno p-value reported

An increasing trend was noted also in the number of CD4 + T cells stained for TIM3 or LAG3 in tumor of SR59230A, αPD-L1 treatments and their combination, but they failed to reach statistical significance.

also in 63,971 other papers

showed a trendno p-value reported

Moreover, a Ki67 staining assay showed a trend indicating an increased proliferation of CD8 + T cells in NB tumors of mice treated with the β3-AR antagonist or PD-L1 antibody, even if it failed to reach significant differences (Fig. 4C ).

also in 53,322 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.