The Prolyl Oligopeptidase Inhibitor KYP-2047 Is Cytoprotective and Anti-Inflammatory in Human Retinal Pigment Epithelial Cells with Defective Proteasomal Clearance.

KYP-2047 tended to increase the levels of p62/SQSTM1 in the MG-132-treated cells, but the effect was not quite statistically significant ( p = 0.0649, Figure 5 B).

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MG-132 significantly increased the levels of IL-8 ( Figure 2 C), and pretreatment of the cells with 0.1 or 1 μM KYP-2047 tended to reduce the IL-8 levels, but the effect did not reach statistical significance ( Figure 2 C, p = 0.0664 for 1μM KYP-2047).

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The trend toward reduced ROS levels that we observed in our cells is in line with their reports on SH-SY5Y cells, which showed a trend toward reduced ROS at 1 μM KYP-2047 and became significant only at 10 μM [ 7 ].

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