SerpinB3 Upregulates Low-Density Lipoprotein Receptor-Related Protein (LRP) Family Members, Leading to Wnt Signaling Activation and Increased Cell Survival and Invasiveness.

When samples were divided according to the extent of SerpinB3 expression, tumors expressing a high level of SerpinB3 (>median value) showed a trend toward higher amounts of Wnt-1 and Wnt-7a compared to the corresponding figures observed in tumors with low SB3 level (<median value), although the difference did not reach statistical significance, probably due to the small sample size ( Supplementary Figure S1 ).

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