Sex and Age Differences in a Progressive Synucleinopathy Mouse Model.

Biomolecules · 2023 · PMC10296285 · PMID 37371557

Europe PMC DOI

hedged sentences

0.0579

closest p · 1.2× alpha

0.0579

boldest claim

The sentences

did not reach statistical significancep = 0.0579so close (0.05 < p ≤ 0.1)

Although the IL-4 levels appeared to be higher in the male than in the female mice, the differences did not reach statistical significance (wildtype: sex factor F (1.22) = 4.00, p = 0.0579; SNCA-/-: sex factor F (1.20) = 2.09, p = 0.1635; SNCA-OVX: sex factor F (1.23) = 3.42, p = 0.0773; Figure S2A(i) ).

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showed a trendno p-value reported

Moreover, our results showed a trend of higher levels of this protein in the females compared to the males, which could be explained by the capacity of the estrogen receptor alpha to modulate αSyn expression [ 59 ].

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