The Impact of Polymorphisms in ATP-Binding Cassette Transporter Genes on Anthracycline-Induced Early Cardiotoxicity in Patients with Breast Cancer.

J Cardiovasc Dev Dis · 2023 · PMC10299506 · PMID 37367397

Europe PMC DOI

hedged sentences

0.0480

closest p · 1.0× alpha

0.0480

boldest claim

The sentences

nominally significantp = 0.048actually significant

observed that ABCB1 rs1045642 has an additive protective effect against cardiotoxicity (OR = 0.48, 95% CI = 0.23–1.00, p = 0.049), and the results remained nominally significant after correction for clinical covariates ( p = 0.048) [ 48 ].

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did not reach statistical significanceno p-value reported

The results of univariate and multivariate logistic regression analyses showed the potential cardioprotective effect of the rs1045642 heterozygous genotype, but it did not reach statistical significance.

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