New Insights into the Fluid Management in Patients with Septic Shock.

However, two RCTs, the Saline versus Albumin Fluid Evaluation (SAFE) and the Albumin Italian Outcome Sepsis (ALBIOS) study, as well as a meta-analysis of randomized clinical trials, compared the effect of albumin and crystalloid use in patients with sepsis or septic shock, and showed a trend towards reduced mortality and improved outcomes in the albumin group, without observing serious side effects [ 63 , 64 , 65 ].

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In this study, CRT-guided resuscitation resulted in a significantly lower SOFA score at 72 h, and in a lower 28-day mortality that did not reach statistical significance.

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