In contrast, spermine shows an increasing trend with aging in various organs ( Wilkinson et al., 2020 ; Nagineni et al., 2021 ).
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The sentences
In general, the NAD + levels decreased relatively in aging organs, while ROS showed a trend of continuous accumulation.
The remaining 24 metabolites showed different trends with aging in different species as well as in different tissues, and overall there did not seem to be a clear trend associated with aging.