The Combined Effects of Sublingual Immunotherapy and Lactobacillus acidophilus-Producing Extract on Cedar Pollinosis Symptoms.

All groups experienced improved symptoms over time, with the L and SL groups showing near-significant improvement by Year 3 (p < 0.1).

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Based on the severity and quality of life scores, it was expected that the S and SL groups would require three years of treatment before the onset of efficacy, while the L group showed a trend toward improvement in quality of life scores and cedar pollen-specific IgE levels from the first year of treatment, suggesting that an early onset of efficacy can be expected for LEX. and LEX was not clear.

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In the S and SL groups, IgE-RAST showed an increasing trend in the first year of treatment, returned to the same level as before the start of treatment (before pollen dispersal) in the second year, and showed a decreasing trend in the third year.

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The IgE-RIST before the start of treatment (before pollen dispersal) was greater in the L, SL, and S groups, in that order, but there were no significant differences among the groups; in the S group, an increasing trend was observed in the IgE-RIST during the pollen dispersal period in the first year of treatment, but no significant changes were observed in the SL and L groups during the study period.

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