Although CST did not reach statistical significance with regard to rehospitalizations, we found that a higher plasma CST concentration increased the risk of all-cause death by more than five times.
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Prognostic Value of Plasma Catestatin Concentration in Patients with Heart Failure with Reduced Ejection Fraction in Two-Year Follow-Up.
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were not significantly different between the three LVEF phenotypes, the investigators noted a clear trend towards higher CST levels in HFrEF patients, although statistical significance was not reached, most likely due to limited sample size.