Differential Modulation of GABAergic and Glutamatergic Neurons in the Ventral Pallidum by GABA and Neuropeptides.

To estimate whether the weaker synaptic strength of D1-MSNs onto GAD2(–) could be explained by lower GABA release probability, we quantified paired-pulse ratios in response to four different interstimulus intervals (ISIs) and found a strong trend toward higher ISIs for D1-MSN to GAD2(–) synapses ( Fig. 1 D , left; F (1,81) = 3.486, p = 0.065, cell type, two-way ANOVA).

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Evoked IPSCs showed a trend toward increase in paired-pulse ratio after DAMGO application, and evoked EPSCs showed a significant increase ( Fig. 3 C , right; t (5) = 2.023, p = 0.1; t (5) = 13.06, p < 0.01; paired t test), indicating that the inhibition of EPSCs was based on the decrease of glutamate release probability.

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