Assessing attention and impulsivity in the variable stimulus duration and variable intertrial interval rodent continuous performance test schedules using dopamine receptor antagonists in female C57BL/6JRj mice.

Psychopharmacology (Berl) · 2023 · PMC10349733 · PMID 37378887

Europe PMC DOI

hedged sentences

0.0580

closest p · 1.2× alpha

0.0720

boldest claim

The sentences

near-significantP =0.058so close (0.05 < p ≤ 0.1)

The dose:reference interaction was near-significant for the 0.02 mg/kg dose ( P =0.058) and significant for the 0.04 mg/kg dose ( P <0.01), which showed a stronger effect in high-HR mice.

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showed a trendP =0.072so close (0.05 < p ≤ 0.1)

The 0.01 mg/kg dose showed a trend towards dose:reference interaction ( P =0.072), where a positive slope indicates that 0.01 mg/kg SCH worsens performance in low-d’ mice and improved performance in high-d’ mice. %Acc was significantly increased by 0.02 ( P <0.01) and 0.04 mg/kg SCH ( P <0.001), and a trend effect was seen at 0.01 mg/kg ( P =0.055).

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