GSTM1 and GSTT1 polymorphisms associated with pain in a chemotherapy-induced peripheral neuropathy cohort.

Longitudinal stratification of the CIPN phenotypes to examine links for neuropathy, identified nominally significant protective associations with the GSTM* null allele ( p -value = 0.038, OR = 0.55) and the presence of pain at month 2 of treatment, as well as a risk factor for pain related month 2 of treatment for individuals with the GSTT1* null allele ( p -value = 0.030, OR = 1.64).

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We did not identify an association with any of the GST markers and CIPN in this cohort, however, the GSTM1- null allele was approaching significance with a p -value of 0.0617 (Table 2 ).

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