Yeast Models of Amyotrophic Lateral Sclerosis Type 8 Mimic Phenotypes Seen in Mammalian Cells Expressing Mutant VAPB^P56S.

Using this approach, we found that the inclusion-like structures were similar in size for WT, scs2 ∆ and scs22 ∆ cells; although scs2 ∆ cells showed a trend toward slightly larger inclusions, this was not a statistically significant difference ( p = 0.1283; Figure 1 B).

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While there was a trend toward a further increase in size for scs2 ∆ scs22 ∆ + scs2 P51S, P58S cells compared to scs2 ∆ scs22 ∆, this result failed to reach statistical significance.

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