Differential responses of pulmonary vascular cells from PAH patients and controls to TNFα and the effect of the BET inhibitor JQ1.

There was a large and highly significant (p < 0.0001) increase in IL-8 mRNA at 2 h in response to TNFα in both control and PAH endothelial cells.

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JQ1+, but not JQ1-, also decreased the large increase in TNFα-stimulated IL-8 mRNA induction in HPASMC from controls and PAH patients by 80–90% but this did not reach statistical significance (Fig. 6 C and D).

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JQ1 + also decreased TNFα-stimulated recruitment of BRD4 to the IL-8 κB site to near basal levels but this failed to reach statistical significance (Fig. 4 G and H).

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This increase was significant (p < 0.01) in controls but failed to reach significance in cells from patients with PAH.

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