A meta-analysis of immune-cell fractions at high resolution reveals novel associations with common phenotypes and health outcomes.

For instance, our meta-analysis revealed a clear trend for basophil and NK-cell fractions to increase with age (Fig. 2 a, Stouffer Z = 11, P < 10 −20 for NK and Z = 10, P < 10 −20 for basophils), strengthening preliminary findings from others [ 90 – 93 ].

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Hence, selecting the top-ranked 50 according to Δ pt values ensures that we are selecting not only highly significant hypomethylated probes but also those with the largest possible effect sizes.

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2 a, Stouffer P = 0.03), the marginal significance being driven entirely by one study (Song et al.

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Although associations with alcohol consumption were only of marginal significance, it is worth noting that the specific increases of CD4T cells (both naïve and memory subsets) and basophils in frequent drinkers were replicated at a similar significance level in the TZH cohort (Additional File 2 : fig.S16).

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