Dietary restriction mitigates the age-associated decline in mouse B cell receptor repertoire diversity.

Cell Rep · 2023 · PMC10391628 · PMID 37384530

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a strong trendno p-value reported

At 20 months of age, DR animals showed a strong trend of increased IgM and IgG abundance at the expense of IgA compared to 5-month-old animals.

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a clear trendno p-value reported

DR mice exhibited significantly increased Shannon and Simpson diversity with age in IgE, and there was also a clear trend for DR to attenuate age-related changes in IgG, and at old age also in IgM ( Figures S2 A and S2B).

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