Measurement of NF-κB activity in SF3B1 WT and SF3B1 K700E cell lines showed a trend towards an increase of the active p65 form and of the ratio between phosphorylated p65 and total p65 in SF3B1 K700E samples, although they did not reach statistical significance ( Fig 5D and E ).
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<i>SF3B1</i> mutation-mediated sensitization to H3B-8800 splicing inhibitor in chronic lymphocytic leukemia.
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