Factors predictive of clinical outcome in advanced hepatocellular carcinoma patients receiving ramucirumab treatment: A real-world experience.

Cancer Med · 2023 · PMC10417170 · PMID 37278402

Europe PMC DOI

hedged sentences

—

closest p

—

boldest claim

The sentences

failed to reach statistical significanceno p-value reported

In previous reports, anti‐VEGF agents were able to modulate immune function and enhance T cell antitumor activity, 25 , 26 which might explain why single agents with an immune checkpoint inhibitor (ICI) such as pembrolizumab and nivolumab failed to reach statistical significance, 27 , 28 while combining an anti‐VEGF agent with ICI improved clinical outcomes significantly. 10 This points to the immunomodulator effect of the anti‐VEGF agents.

also in 6,035 other papers

did not reach statistical significanceno p-value reported

In subgroup analysis of the REACH trial, 3 patients with higher AFP levels showed better survival outcomes, although the trial did not reach statistical significance.

also in 111,027 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.