Prolonged cytopenia following CD19 CAR T cell therapy is linked with bone marrow infiltration of clonally expanded IFNγ-expressing CD8 T cells.

This revealed a highly significant enrichment of inflammation-associated pathways such as interferon gamma (IFN-γ) response (SCPA adjusted p value <0.05) and multiple DNA repair pathway gene sets within C0:CD8 T cells from the bone marrow of patients with PC ( Figure 2 B and Table S5 ).

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Within a subset of cases with available data from pre-treatment peripheral blood sequencing, 17 clonal hematopoiesis of indeterminate potential was found to be slightly more frequent in patients with PC (15/30, 50%) compared to those without (7/24, 29%), but this did not reach statistical significance (Fisher p = 0.166; Figure S1 A).

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We have focused on the expansion of CX3CR1 + IFNγ-producing CD8 T cells that had significant differences in frequency within our population; however, there may be other reproducible but lower-magnitude changes that failed to reach statistical significance due to our limited sample size.

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