T cell activation is insufficient to drive SIV disease progression.

During chronic infection, a delay of CD4 + T cell restoration was observed in Ontak-treated AGMs, resulting in slightly lower levels of circulating CD4 + T cell counts than in controls; yet these differences did not reach statistical significance ( P = 0.19).

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As for the CD25 hi CD4 + T cells, the FoxP3 + CD4 + Tregs showed a trend toward transient rebound at 21 days after treatment initiation, which was reversed by additional administrations of the immunotoxin ( Figure 1B ).

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