A MYCN-independent mechanism mediating secretome reprogramming and metastasis in <i>MYCN</i>-amplified neuroblastoma.

S7C), accompanied by a strong trend toward increased bone metastasis (fig.

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Moreover, MYO1B depletion was also associated with a decrease in NB cell extravasation, but the difference did not quite reach statistical significance (fig.

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Nonetheless, we observed a highly significant correlation between GREB1 and MYCN expression in five independent cohorts of NB tumor samples (fig.

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Notably, GREB1 expression is not induced by MYCN, as MYCN depletion in Tet21N cells that express MYCN cDNA under the control of a Tet-Off system failed to reduce GREB1 levels and instead showed a trend toward increased GREB1 expression (fig.

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