Dimethyl Sulfoxide Inhibits Bile Acid Synthesis in Healthy Mice but Does Not Protect Mice from Bile-Acid-Induced Liver Damage.

Daily DMSO gavage reduced the mean of hepatic Cyp8b1 expression but did not reach statistical significance ( p = 0.14), largely due to the very high intragroup variation ( Figure 3 B).

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Cyp27a1 was significantly suppressed by the higher dose of DMSO treatment, while Cyp7a1 and Cyp8b1 also showed a trend of decreasing expression but without statistical significance ( Figure 2 B).

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