Skin Gene Expression Profiles in Systemic Sclerosis: From Clinical Stratification to Precision Medicine.

Int J Mol Sci · 2023 · PMC10454358 · PMID 37628728

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a strong trendno p-value reported

In the phase II faSScinate study, which investigated TCZ use in SSc patients, there was a trend toward benefits in terms of the primary endpoint, mRSS, and a strong trend at 48 weeks, along with consistent benefits in exploratory endpoints, including lung function [ 56 ].

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showed a trendno p-value reported

placebo, SSc patients with an inflammatory intrinsic subset showed a trend toward greater improvement in skin score at 24 weeks compared to patients in the normal-like intrinsic subset [ 58 ].

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