Efficacy and safety of vonoprazan-amoxicillin dual therapy for <i>Helicobacter pylori</i> first-line treatment: a single-center, randomized, controlled trial.

Ther Adv Gastroenterol · 2023 · PMC10469240 · PMID 37664169

Europe PMC DOI

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did not reach statistical significanceno p-value reported

But due to the relatively small sample size, the difference did not reach statistical significance.

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highly significantno p-value reported

pylori eradication and that intragastric pH has a highly significant impact on the effectiveness of amoxicillin.

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failed to reach statistical significanceno p-value reported

Third, this study was a noninferior study with a relatively small sample size so the superiority test failed to reach statistical significance, especially in clarithromycin-resistant strains.

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