Combating pan-coronavirus infection by indomethacin through simultaneously inhibiting viral replication and inflammatory response.

1 SARS-CoV-2, infecting both the upper and lower respiratory tract, has caused over 6 million deaths worldwide until May 2023, but this virus is continuously evolving showing a clear trend toward less pathogenic, in particular the Omicron variant. 2 , 3 , 4 Seasonal coronaviruses primarily infect the upper respiratory tract and only cause the common cold.

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37 Meta-analysis of four studies showed a moderate improvement for recovery but did not reach statistical significance. 38 Overall, indomethacin monotherapy is likely insufficient to effectively clear coronavirus infection in patients.

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