Notably, animals challenged 6 months post-vaccination, showed lower viral titers compared to unvaccinated mice, although this did not reach statistical significance ( Figure 1 D).
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BCG administration promotes the long-term protection afforded by a single-dose intranasal adenovirus-based SARS-CoV-2 vaccine.
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The sentences
Our antigen-specific assay demonstrated that although Ad(Spike) alone showed a trend toward increased expression of cytotoxic activity in antigen-primed T cells, these differences became significant only in mice that were pre-immunized with BCG.