URAT1 is expressed in cardiomyocytes and dotinurad attenuates the development of diet-induced metabolic heart disease.

1 , 25 When NRCMs were exposed to a high concentration of PA (200 μM) for 24 h, the XO-derived H 2 O 2 levels (namely, the XO activity) in NRCMs increased compared to the control, although the difference did not reach statistical significance (p = 0.0504).

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The cardiac expression of CD68, a valuable macrophage marker in the histochemical analysis of inflamed tissues, 16 showed a trend toward an increase in HFD-fed mice in comparison to NFD-fed mice (p = 0.08), although dotinurad did not reduce it ( Figure S1 A).

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