Modifying immune responses to adeno-associated virus vectors by capsid engineering.

Mol Ther Methods Clin Dev · 2023 · PMC10485635 · PMID 37693943

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failed to reach statistical significanceno p-value reported

as well as at 5 d p.i., a higher transgene mRNA level for AAV2.MB453 compared with AAV2 was observed, which failed to reach statistical significance ( Figures 3 D, 3E, and S11 D).

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did not reach statistical significanceno p-value reported

Differences observed for transgene-specific and capsid-specific CD8 + T cells between AAV2 and AAV2.MB453 vector-treated cohorts did not reach statistical significance ( Figures 6 E and 6F).

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