Transcriptional immunogenomic analysis reveals distinct immunological clusters in paediatric nervous system tumours.

Genome Med · 2023 · PMC10486055 · PMID 37679810

Europe PMC DOI

hedged sentences

0.0500

closest p · 1.0× alpha

0.1000

boldest claim

The sentences

did not reach statistical significancep > 0.05actually significant

MYC-like ATRTs appeared to be enriched in Paediatric Inflamed or Myeloid Predominant compared to non-MYC-like ATRT, and 8 out of 12 SHH-like ATRT tumours clustered into Immune Neutral, although it did not reach statistical significance (one-sided Fisher’s exact test with Bonferroni correction, p > 0.05) [ 84 ].

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showed a trendp = 0.1so close (0.05 < p ≤ 0.1)

In neuroblastoma ( n = 148), MYCN non-amplified neuroblastoma cases were enriched in Myeloid Predominant ( n = 41, p = 0.007), while neuroblastoma MYCN amplified showed a trend toward Immune Desert ( n = 16, p = 0.1) [ 90 , 91 ].

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