Fluid shear stress induces a shift from glycolytic to amino acid pathway in human trophoblasts.

Although it did not reach statistical significance (Fig. 4 d), the results were in good agreement with significantly downregulated HK2 expression.

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However, pyruvate levels did not significantly increase, at least by using this method, although a statistical trend for increase could be confirmed (Fig. 4 a).

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Placental tissue from pregnancies with intrauterine growth restriction are exposed to high shear rates and showed also decreased glutamic-oxaloacetic transaminase 2, while GLUT1 was unchanged and glycolytic rate-limiting enzymes showed a trend to be upregulated.

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