Arsenic trioxide demonstrates efficacy in a mouse model of preclinical systemic sclerosis.

Arthritis Res Ther · 2023 · PMC10496169 · PMID 37700377

Europe PMC DOI

hedged sentences

0.0710

closest p · 1.4× alpha

0.1700

boldest claim

The sentences

a slight trendp = 0.071so close (0.05 < p ≤ 0.1)

From the 4th week of treatment, a slight trend towards a decreased clinical score was observed in the ATO-treated Fra2 TG mice as compared to the PBS group (median score [IQR]: 1 [1–2.75] vs. 2 [1–4]; p = 0.071) (Fig.

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did not reach statistical significancep = 0.17not close (p > 0.1)

Although ATO treatment led to a 50% reduction in fibrillar collagen deposits compared to PBS treatment, this difference did not reach statistical significance (6.53 [4.5–19.52] vs. 13.13 [7.41–22.79]; p = 0.17) (Fig. 2 B).

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showed a trendno p-value reported

Other investigations of fibrotic markers showed a trend of reduction in various measurements of fibrosis, but the differences did not reach significance.

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