Meanwhile, lipid levels in children and adolescents also showed an elevated trend.
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The sentences
10.4 Combinations of lipid-lowering drugs The combination application of lipid-lowering drugs is an important trend in dyslipidemia intervention strategies, with the main aim of improving lipid target rates, further reducing cardiovascular risk, and reducing the incidence of adverse effects of lipid-lowering drugs.
As a result, China is facing an increasing trend of ASCVD disease burden, and lipid management is urgent.
Reduction of Cardiovascular Events with Icosapent Ethyl-Intervention Trial (REDUCE-IT) and the Japan Eicosapentaenoic Acid Lipid Intervention Study (JELIS) showed that combining high-purity IPE or EPA with a statin significantly reduced ASCVD risk ( Yokoyama et al., 2007 ; Bhatt et al., 2019 ), while studies of statins combined with high-purity omega-3 fatty acids (EPA + DHA) showed a trend toward ASCVD reduction only in the meta-analysis ( Hu et al., 2019 ). 9.5 Monitoring of treatment process The purpose of monitoring in lipid-lowering therapy are: 1) to observe whether the lipid-lowering target value is achieved; 2) to understand the potential adverse effects of drugs.