Systematic review and meta-analysis: does pre-implantation genetic testing for aneuploidy at the blastocyst stage improve live birth rate?

J Assist Reprod Genet · 2023 · PMC10504192 · PMID 37479946

Europe PMC DOI

hedged sentences

0.0200

closest p · 0.4× alpha

0.4200

boldest claim

The sentences

showed a trendp = 0.02actually significant

The pooled RCT data showed a trend for higher miscarriage rate in the control group, which was statistically significant (RR 0.73, 95% CI 0.56–0.96; p = 0.02).

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did not reach statistical significancep = 0.42not close (p > 0.1)

Amongst the pooled cohort studies, higher multiple pregnancy rates were observed in the control compared to PGT-A groups, but this did not reach statistical significance (RR 0.64, 95% CI 0.22–1.90; p = 0.42).

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