IGF-1 and Risk of Morbidity and Mortality From Cancer, Cardiovascular Diseases, and All Causes in EPIC-Heidelberg.

J Clin Endocrinol Metab · 2023 · PMC10505533 · PMID 37066827

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a significant trendno p-value reported

However, the hazard ratios across the quintiles as well as dose-response plots suggested a U-shaped relationship, with a significant trend observed for hazards of mortality between Q1 and Q3 ( Table 3 and Fig. 2 ).

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did not reach statistical significanceno p-value reported

Regarding mortality from cardiovascular causes, although hazards of mortality were higher among participants at both extremes of the IGF-1 distribution, they did not reach statistical significance.

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