Interaction analysis of high-risk pathological features on adjuvant chemotherapy survival benefit in stage II colon cancer patients: a multi-center, retrospective study.

BMC Cancer · 2023 · PMC10506231 · PMID 37718392

Europe PMC DOI

hedged sentences

0.0580

closest p · 1.2× alpha

0.0580

boldest claim

The sentences

reached borderline significanceP = 0.058so close (0.05 < p ≤ 0.1)

Sex, age, ASA classification were independent risk factors for DFS (HR 1.563, 95% CI 1.021–2.394, P = 0.040; HR 1.034, 95% CI 1.015–1.052, P < 0.001; HR 2.228, 95% CI 1.386–3.584, P < 0.001, respectively), and the prognostic effect of PNI on DFS reached borderline significance (HR 1.583, 95% CI 0.985–2.545, P = 0.058) (Table 3 ).

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marginally significantno p-value reported

We spotted a marginally significant ACT benefit on DFS and OS in patients with PNI (Fig. 2 ), however, no significant benefits were observed in other clinicopathological subgroups.

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showed a trendno p-value reported

In our study, patients with T4 tumors also showed a trend of improved survival from ACT.

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