No statistically significant changes in disease severity were observed either, although a clear trend of disease attenuation was observed ( Supplementary Figures S3A – D ), as opposed to lean mice.
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The sentences
The BLM-induced weight loss, an indicator of overall systemic health, did not reach statistical significance in Lcn2 −/− mice ( Figure 6C ); however, no statistically significant changes were detected in vascular leak ( Figure 6D ), inflammation ( Figure 6E ), or soluble BALF collagen ( Figure 6F ).