Gait disorders induced by photothrombotic cerebellar stroke in mice.

A post hoc statistical test identified a significant increase in the rate of missteps in the stroke group (pre-test, 11.0 ± 2.1%; post-test, 13.5 ± 1.3%, p = 0.040; mean ± SD); the sham treatment group showed a trend of decreasing missteps (pre-test, 10.4 ± 2.0%; post-test, 8.1 ± 1.7%, p = 0.051; mean ± SD), whereas the stroke group had a higher rate of missteps compared to the sham treatment group at the post-test (p < 0.001) (Fig. 2 B, Supplementary Table S1 online).

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3 C) in the stroke group; in particular, knee angle at E3-F and F-E1 showed hyperflexion compared to the pre-test (E3-F pre = 70.8 ± 4.4 deg; E3-F post = 60.2 ± 3.9 deg, p = 0.027; F-E1 pre = 45.2 ± 2.8 deg; F-E1 post = 38.1 ± 2.4 deg, p = 0.026), although the interaction of both E3-F and F-E1 knee angles did not reach statistical significance (Table 1 ).

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