Selective Noradrenaline Depletion in the Neocortex and Hippocampus Induces Working Memory Deficits and Regional Occurrence of Pathological Proteins.

By contrast, the levels of phosphorylated TDP-43 in the cortex and hippocampus of the HD group were increased (by about 50%) compared to the CTL and LD groups, but only the former was significant ( p < 0.05; Figure 5 A–C), whereas the hippocampal increase failed to reach statistical significance ( p = 0.079; Figure 5 D–F). 3.6.

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Furthermore, we found a strong trend for an increase in pTDP-43 levels in the hippocampus of the HD group.

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High Dose of Anti-DBH-Saporin Leads to an Increase in TDP-43 Phosphorylated at Ser 409/410 in the Cortex In a previous study, a highly significant correlation was found between the depletion of noradrenergic fibers in the hippocampal dentate gyrus (DG) and the cytoplasmic mislocalization of TDP-43 immunoreactivity in DG neurons [ 37 ].

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