Although the primary objective was met and the safety profile seemed more favorable than that of alglucosidase alfa, superiority testing did not reach statistical significance [ 169 ].
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The sentences
In IOPD, a 6-month primary analysis of the mini-COMET study recently showed a trend toward improvement or stabilization of clinical outcomes and a good safety profile, with better results for patients treated with avalglucosidase alfa 40 mg/kg every 2 weeks [ 171 ].