Vascular endothelial cell-specific disruption of the <i>profilin1</i> gene leads to severe multiorgan pathology and inflammation causing mortality.

Although the P -value (0.09) did not reach statistical significance (because of large animal-to-animal variation), monocytes/macrophages from Pfn1 EC-KO mice indeed showed a trend of higher IL6 expression relative to those harvested from Pfn1 WT mice (Fig. 6 F).

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Pfn1 EC-KO animals also displayed a general trend of increase in the circulating levels of GM-CSF, M-CSF, KC/CXCL1, and RANTES/CCL5, but these changes did not reach statistical significance due to larger animal-to-animal variation.

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