Protective effect of pre-existing natural immunity in a nonhuman primate reinfection model of congenital cytomegalovirus infection.

PLoS Pathog · 2023 · PMC10553354 · PMID 37796819

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0.2500

closest p · 5.0× alpha

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did not reach statistical significancep-value = 0.25not close (p > 0.1)

Concurrently, there was also an expansion of lineage (Lin) – HLA-DR hi dendritic cells, Lin – HLA-DR – SSC hi CD14 + putative myeloid-derived suppressor cells (MDSC) and a transient decline in circulating B lymphocytes which did not reach statistical significance (p-value = 0.25; non-parametric Wilcoxon Signed Rank test) ( Figs 3 and S1A–S1C ) .

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showed a trendno p-value reported

Boolean analysis of all four effector functions showed a trend for decreased proportion of monofunctional and increased proportion of polyfunctional RhCMV-specific CD8+ T cell responses post reinfection ( P- value 0.11; Fig 4B ).

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