Extracorporeal cytokine adsorption reduces systemic cytokine storm and improves graft function in lung transplantation.

In the treatment-group, there was a significant trend of lower levels of proinflammatory cytokine interleukin (IL)-2 during 6-hour adsorption compared to the control group ( P = .01).

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Specifically, there was a weak trend toward a lower percentage of lymphocytes in the BAL of treatment group ( P = .2888), but no significant differences were found in the percentage counts of neutrophils and monocytes ( P = .776, P = .664, respectively).

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In addition, there was a nonsignificant trend towards lower proinflammatory cytokines tumor necrosis factor-α, IL-1α, and granulocyte-macrophage colony-stimulating factor in the adsorber group during the 6-hour treatment period ( P = .172, P = .186, P = .130, respectively).

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Histologically, the treatment group had a strong trend, indicating less neutrophil invasion into the alveolar space.

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