Gestational Early-Time Restricted Feeding Results in Sex-Specific Glucose Intolerance in Adult Male Mice.

Although the latter was exploratory and did not reach statistical significance, the other study of gestational (12-hour) TRF of a chow diet in rats also found evidence of glucose intolerance and insulin sensitivity in the offspring of TRF dams [ 19 ].

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There was a nonsignificant trend toward lower insulin levels in eTRF compared to AL offspring of both sexes ( p diet = 0.071).

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This study was not conclusive as it had a lower sample size and failed to reach statistical significance but could indicate that insulin secretion is modestly impaired in male eTRF offspring after HFHS challenge in males. 4.

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