Loss of CD4<sup>+</sup> T cell-intrinsic arginase 1 accelerates Th1 response kinetics and reduces lung pathology during influenza infection.

Arg1 -deficient CD8 + T lymphocytes (both total lung CD8 + T cells and CD11a + CD49d + CD8 + T cells) showed a trend toward augmented expansion at day 7 p.i., which did not reach statistical significance ( Figures S2G and S2H ).

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in WT mice, CD4 + T cell numbers in Arg1 CKO animals showed a trend toward decline at this time point ( Figure 2C ).

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